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Diabetic Foot Ulcer (DFU): DFU is a complication of diabetes mellitus characterized by a partial or full-thickness open wound with or without discharge. Cracks, fissures, or ulcers form as a result of acute trauma, callous formation, or repeated/persistent trauma. DFU may be complicated by pain and/or neuropathy. Neuropathic Foot Ulcer: Neuropathic foot ulcers can occur in the absence of diabetes.